Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction

Sammy Alhassen; Siwei Chen; Lamees Alhassen; Alvin Phan; Mohammad Khoudari; Angele De Silva; Huda Barhoosh; Zitong Wang; Chelsea Parrocha; Emily Shapiro; Charity Henrich; Zicheng Wang; Leon Mutesa; Pierre Baldi; Geoffrey W. Abbott; Amal Alachkar

doi:10.1038/s42003-021-02255-2

Communications Biology (Jun 2021)

Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction

Sammy Alhassen,
Siwei Chen,
Lamees Alhassen,
Alvin Phan,
Mohammad Khoudari,
Angele De Silva,
Huda Barhoosh,
Zitong Wang,
Chelsea Parrocha,
Emily Shapiro,
Charity Henrich,
Zicheng Wang,
Leon Mutesa,
Pierre Baldi,
Geoffrey W. Abbott,
Amal Alachkar

Affiliations

Sammy Alhassen: Department of Pharmaceutical Sciences, University of California
Siwei Chen: Department of Computer Science, School of Information and Computer Sciences, University of California
Lamees Alhassen: Department of Pharmaceutical Sciences, University of California
Alvin Phan: Department of Pharmaceutical Sciences, University of California
Mohammad Khoudari: Department of Pharmaceutical Sciences, University of California
Angele De Silva: Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California
Huda Barhoosh: Department of Pharmaceutical Sciences, University of California
Zitong Wang: Department of Pharmaceutical Sciences, University of California
Chelsea Parrocha: Department of Pharmaceutical Sciences, University of California
Emily Shapiro: Department of Pharmaceutical Sciences, University of California
Charity Henrich: Department of Pharmaceutical Sciences, University of California
Zicheng Wang: Department of Pharmaceutical Sciences, University of California
Leon Mutesa: Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda
Pierre Baldi: Department of Computer Science, School of Information and Computer Sciences, University of California
Geoffrey W. Abbott: Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California
Amal Alachkar: Department of Pharmaceutical Sciences, University of California

DOI: https://doi.org/10.1038/s42003-021-02255-2
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

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Sammy Alhassen, Siwei Chen, et al. use mouse models to examine the effects of prenatal and postnatal stress on metabolomic and transcriptomic pathways in the brain. Their results suggest that altered mitochondrial metabolism may underlie trauma-induced behavioral deficits, and that correcting metabolism with ALCAR supplementation may protect against intergenerational transmission of traumatic stress.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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