Nature Communications (May 2021)
Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance
- Mayura V. Wagle,
- Stephin J. Vervoort,
- Madison J. Kelly,
- Willem Van Der Byl,
- Timothy J. Peters,
- Ben P. Martin,
- Luciano G. Martelotto,
- Simone Nüssing,
- Kelly M. Ramsbottom,
- James R. Torpy,
- Deborah Knight,
- Sinead Reading,
- Kevin Thia,
- Lisa A. Miosge,
- Debbie R. Howard,
- Renee Gloury,
- Sarah S. Gabriel,
- Daniel T. Utzschneider,
- Jane Oliaro,
- Jonathan D. Powell,
- Fabio Luciani,
- Joseph A. Trapani,
- Ricky W. Johnstone,
- Axel Kallies,
- Christopher C. Goodnow,
- Ian A. Parish
Affiliations
- Mayura V. Wagle
- John Curtin School of Medical Research, Australian National University
- Stephin J. Vervoort
- Peter MacCallum Cancer Centre
- Madison J. Kelly
- Peter MacCallum Cancer Centre
- Willem Van Der Byl
- The Kirby Institute for Infection and Immunity, UNSW
- Timothy J. Peters
- Garvan Institute of Medical Research
- Ben P. Martin
- Peter MacCallum Cancer Centre
- Luciano G. Martelotto
- Centre for Cancer Research, VCCC, University of Melbourne
- Simone Nüssing
- Peter MacCallum Cancer Centre
- Kelly M. Ramsbottom
- Peter MacCallum Cancer Centre
- James R. Torpy
- Garvan Institute of Medical Research
- Deborah Knight
- Peter MacCallum Cancer Centre
- Sinead Reading
- Peter MacCallum Cancer Centre
- Kevin Thia
- Peter MacCallum Cancer Centre
- Lisa A. Miosge
- John Curtin School of Medical Research, Australian National University
- Debbie R. Howard
- John Curtin School of Medical Research, Australian National University
- Renee Gloury
- The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Sarah S. Gabriel
- The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Daniel T. Utzschneider
- The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Jane Oliaro
- Peter MacCallum Cancer Centre
- Jonathan D. Powell
- Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University of Medicine
- Fabio Luciani
- The Kirby Institute for Infection and Immunity, UNSW
- Joseph A. Trapani
- Peter MacCallum Cancer Centre
- Ricky W. Johnstone
- Peter MacCallum Cancer Centre
- Axel Kallies
- The Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Christopher C. Goodnow
- John Curtin School of Medical Research, Australian National University
- Ian A. Parish
- John Curtin School of Medical Research, Australian National University
- DOI
- https://doi.org/10.1038/s41467-021-23044-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models induces the expression of EGR2, which drives and stabilises exhausted cell epigenetic and transcriptional identity.
