Journal of Pure and Applied Microbiology (Jun 2021)

COVID-19 and Diabetes Mellitus: A Complex Interplay

  • Gopala Koneru,
  • Hager H. Sayed,
  • Nayera A. Abd-elhamed,
  • Nouran Elsedfy,
  • Amira H. Mohamed,
  • Hania A. Abdellatif,
  • Fatmaalzharaa F. Mohamed,
  • Esraa H. Bahnasawy,
  • Nayera K. Mousa,
  • Aml Eisa,
  • Esraa A. Elshenawy,
  • Yassmin Z. Basheer,
  • Esraa H. Sayed,
  • Farah F. Mohamed,
  • Walaa R. Ali,
  • Hadir A. Soliman,
  • Ashrakt A. Eltabary,
  • Noorhan M. Sayed,
  • Nourhan H. Nasr,
  • Nour S. Khairallah,
  • Helal F. Hetta

DOI
https://doi.org/10.22207/JPAM.15.2.16
Journal volume & issue
Vol. 15, no. 2
pp. 512 – 523

Abstract

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COVID-19 pandemic, which caused by the newly emerged severe acute respiratory syndrome coronavirus-2 (SARS- CoV-2), puts the entire world in an unprecedented crisis, leaving behind huge human losses and serious socio-economical damages. The clinical spectrum of COVID-19 varies from asymptomatic to multi-organ manifestations. Diabetes mellitus (DM) is a chronic inflammatory condition, which associated with metabolic and vascular abnormalities, increases the risk for SARS-CoV-2 infection, severity and mortality. Due to global prevalence, DM effect on COVID-19 outcomes as well as the potential mechanisms by which DM modulates the host-viral interactions and host-immune responses are discussed in this review. This review also highlights the effects of anti-diabetic drugs on treatment of SARS-CoV-2 infection and vice versa.

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