THE CHARACTERIZATION OF PROAPOPTOTIC ACTIVITY OF LIPOPOLYSACCHARIDE IN ISOLATED SUBPOPULATIONS OF HUMAN T-LYMPHOCYTES

Abstract

Lipopolysaccharide (LPS) is used as activator and inductor of immune cells apoptosis in case of infectious processes modeling. It is not clear if LPS is direct inductor of apoptosis in human T-cells. The subpopulations of effector and naive CD4+ T-helper and CD8+ cytotoxic T lymphocytes of human peripheric blood were isolated and cultivated in presence of LPS. It has been shown that LPS was inductor of apoptosis in studying T-cells populations.

Keywords

• lipopolysaccharide
• t-lymphocytes
• apoptosis