Nature Communications (Dec 2018)

Human genome-wide measurement of drug-responsive regulatory activity

  • Graham D. Johnson,
  • Alejandro Barrera,
  • Ian C. McDowell,
  • Anthony M. D’Ippolito,
  • William H. Majoros,
  • Christopher M. Vockley,
  • Xingyan Wang,
  • Andrew S. Allen,
  • Timothy E. Reddy

DOI
https://doi.org/10.1038/s41467-018-07607-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Quantification of genomic responses to environmental stimuli by current genome-scale assays is limited to indirect measurements or requires knowledge of the transcription factors involved. Here, the authors use genome-wide high-throughput reporter assays to agnostically map enhancer activity in response to glucocorticoid treatment across the human genome.