Nature Communications (Nov 2021)
NUDT2 initiates viral RNA degradation by removal of 5′-phosphates
- Beatrice T. Laudenbach,
- Karsten Krey,
- Quirin Emslander,
- Line Lykke Andersen,
- Alexander Reim,
- Pietro Scaturro,
- Sarah Mundigl,
- Christopher Dächert,
- Katrin Manske,
- Markus Moser,
- Janos Ludwig,
- Dirk Wohlleber,
- Andrea Kröger,
- Marco Binder,
- Andreas Pichlmair
Affiliations
- Beatrice T. Laudenbach
- Technical University of Munich, School of Medicine, Institute of Virology
- Karsten Krey
- Technical University of Munich, School of Medicine, Institute of Virology
- Quirin Emslander
- Technical University of Munich, School of Medicine, Institute of Virology
- Line Lykke Andersen
- Technical University of Munich, School of Medicine, Institute of Virology
- Alexander Reim
- Department of Proteomics and Signal transduction, Max-Planck Institute of Biochemistry
- Pietro Scaturro
- Technical University of Munich, School of Medicine, Institute of Virology
- Sarah Mundigl
- Technical University of Munich, School of Medicine, Institute of Virology
- Christopher Dächert
- Research Group “Dynamics of Early Viral Infection and the Innate Antiviral Response” (division F170), German Cancer Research Center, Heidelberg (DKFZ)
- Katrin Manske
- Technical University of Munich, School of Medicine, Institute of Molecular Immunology
- Markus Moser
- Department of Molecular Medicine, Max-Planck Institute of Biochemistry
- Janos Ludwig
- Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn
- Dirk Wohlleber
- Technical University of Munich, School of Medicine, Institute of Molecular Immunology
- Andrea Kröger
- Otto von Guericke University Magdeburg, Institute for Medical Microbiology
- Marco Binder
- Research Group “Dynamics of Early Viral Infection and the Innate Antiviral Response” (division F170), German Cancer Research Center, Heidelberg (DKFZ)
- Andreas Pichlmair
- Technical University of Munich, School of Medicine, Institute of Virology
- DOI
- https://doi.org/10.1038/s41467-021-27239-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
RNA of some viruses is protected from degradation by a 5′ triphosphate group. Here the authors identify nudix hydrolase 2 (NUDT2) as novel antiviral defense protein that dephosphorylates viral RNA and thereby enables its degradation.
