Haematologica (Jan 2013)

A prospective study of nutritional status in immunoglobulin light chain amyloidosis

  • Prayman T. Sattianayagam,
  • Thirusha Lane,
  • Zoe Fox,
  • Aviva Petrie,
  • Simon D.J. Gibbs,
  • Jennifer H. Pinney,
  • Signe S. Risom,
  • Dorota M. Rowczenio,
  • Ashutosh D. Wechalekar,
  • Helen J. Lachmann,
  • Janet A. Gilbertson,
  • Philip N. Hawkins,
  • Julian D. Gillmore

DOI
https://doi.org/10.3324/haematol.2012.070359
Journal volume & issue
Vol. 98, no. 1

Abstract

Read online

Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed, treatment-naïve patients with immunoglobulin light chain amyloidosis attending the UK National Amyloidosis Centre. At study entry, 72 of 110 (66%) patients had a PG-SGA score of 4 or over, indicating malnutrition requiring specialist nutritional intervention. Number of amyloidotic organs, elevated alkaline phosphatase, presence of autonomic neuropathy and advanced Mayo disease stage were independently associated with poor nutritional status (P