Nature Communications (Feb 2017)
Small genomic insertions form enhancers that misregulate oncogenes
- Brian J. Abraham,
- Denes Hnisz,
- Abraham S. Weintraub,
- Nicholas Kwiatkowski,
- Charles H. Li,
- Zhaodong Li,
- Nina Weichert-Leahey,
- Sunniyat Rahman,
- Yu Liu,
- Julia Etchin,
- Benshang Li,
- Shuhong Shen,
- Tong Ihn Lee,
- Jinghui Zhang,
- A. Thomas Look,
- Marc R. Mansour,
- Richard A. Young
Affiliations
- Brian J. Abraham
- Whitehead Institute for Biomedical Research
- Denes Hnisz
- Whitehead Institute for Biomedical Research
- Abraham S. Weintraub
- Whitehead Institute for Biomedical Research
- Nicholas Kwiatkowski
- Whitehead Institute for Biomedical Research
- Charles H. Li
- Whitehead Institute for Biomedical Research
- Zhaodong Li
- Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- Nina Weichert-Leahey
- Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- Sunniyat Rahman
- Department of Haematology, UCL Cancer Institute, University College London
- Yu Liu
- Department of Computational Biology, St Jude Children’s Research Hospital
- Julia Etchin
- Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- Benshang Li
- Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
- Shuhong Shen
- Department of Hematology & Oncology, Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
- Tong Ihn Lee
- Whitehead Institute for Biomedical Research
- Jinghui Zhang
- Department of Computational Biology, St Jude Children’s Research Hospital
- A. Thomas Look
- Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School
- Marc R. Mansour
- Department of Haematology, UCL Cancer Institute, University College London
- Richard A. Young
- Whitehead Institute for Biomedical Research
- DOI
- https://doi.org/10.1038/ncomms14385
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Sequencing initiatives have detected multiple types of mutations in cancer. Here the authors, analysing enhancer-targeting sequence data, show that small insertions in transcriptional enhancers are frequently found near oncogenes, and demonstrate how one mutation deregulates expression of LMO2 in leukemia cells.
