Frontiers in Pharmacology (Nov 2022)
Quercetin Suppresses Human Glioblastoma Migration and Invasion via GSK3β/β-catenin/ZEB1 Signaling Pathway
- Bo Chen,
- Bo Chen,
- Xiaoli Li,
- Xiaoli Li,
- Xiaoli Li,
- Lihong Wu,
- Lihong Wu,
- Duanfang Zhou,
- Duanfang Zhou,
- Yi Song,
- Yi Song,
- Limei Zhang,
- Limei Zhang,
- Qiuya Wu,
- Qiuya Wu,
- Qichen He,
- Qichen He,
- Gang Wang,
- Gang Wang,
- Xu Liu,
- Xu Liu,
- Hui Hu,
- Hui Hu,
- Hui Hu,
- Weiying Zhou,
- Weiying Zhou,
- Weiying Zhou
Affiliations
- Bo Chen
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Bo Chen
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Xiaoli Li
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Xiaoli Li
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Xiaoli Li
- Key Laboratory for Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, China
- Lihong Wu
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Lihong Wu
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Duanfang Zhou
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Duanfang Zhou
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Yi Song
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Yi Song
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Limei Zhang
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Limei Zhang
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Qiuya Wu
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Qiuya Wu
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Qichen He
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Qichen He
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Gang Wang
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Gang Wang
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Xu Liu
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Xu Liu
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Hui Hu
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Hui Hu
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Hui Hu
- Chongqing Pharmacodynamic Evaluation Engineering Technology Research Center, Chongqing Medical University, Chongqing, China
- Weiying Zhou
- Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China
- Weiying Zhou
- Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China
- Weiying Zhou
- Key Laboratory for Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, China
- DOI
- https://doi.org/10.3389/fphar.2022.963614
- Journal volume & issue
-
Vol. 13
Abstract
High invasiveness is a biological and clinical characteristic of glioblastoma and predicts poor prognosis of patients. Quercetin, a natural flavonoid compound, exhibits anticancer activity. However, we have a limited understanding of the possible underlying mechanism of quercetin in glioblastoma. In this study, we investigated the anticancer effect of quercetin in human glioblastoma cells. Our results showed that quercetin markedly suppressed the viability of glioblastoma cells in vitro and in vivo, and significantly inhibited glioblastoma cell migration and invasion. Moreover, quercetin reversed EMT-like mesenchymal phenotype and reduced the expression levels of EMT-related markers. Furthermore, we found that quercetin suppressed GSK-3β/β-catenin/ZEB1 signaling in glioblastoma. Taken together, our results demonstrate that quercetin inhibited migration and invasion of human glioma cells by suppressing GSK3β/β-catenin/ZEB1 signaling. Our study provides evidence that quercetin is a promising therapeutic natural compound to treat glioblastoma.
Keywords
- quercetin
- metastasis
- glioblastoma
- epithelial-like mesenchymal transition
- GSK3β/β-catenin/ZEB1 signaling
