Stochastic activation of the response regulator PhoB by noncognate histidine kinases

Abstract

Two-component systems (TCS) are the most prevalent gene regulatory mechanism in bacteria. A typical TCS is comprised of a histidine kinase (HK) and a partner response regulator (RR). Specific environment signals lead to autophosphorylation of different HKs, which in turn act as phosphoryl donors for autophosphorylation of their partner RRs. Nonpartner HKs and RRs also interact, giving rise to cross regulation among TCSs in response to diverse signals.

Keywords

• arcb
• baes
• cell populations
• crec
• cross regulation
• cross talk
• envz
• escherichia coli
• flow cytometry
• gene expression
• gfp
• kdpd
• phoa
• phor
• promoter reporter fusion
• protein phosphorylation
• qsec
• signal transduction
• single-cell
• two-component regulatory system