Metagenomic Diagnosis of Bacterial Infections

Abstract

To test the ability of high-throughput DNA sequencing to detect bacterial pathogens, we used it on DNA from a patient’s feces during and after diarrheal illness. Sequences showing best matches for Campylobacter jejuni were detected only in the illness sample. Various bacteria may be detectable with this metagenomic approach.

Keywords

• high-throughput DNA sequencing
• bacterial infections
• acute diarrhea
• detection
• identification
• diagnosis