Nature Communications (Jun 2018)

Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

  • Mun-Kit Choy,
  • Biola M. Javierre,
  • Simon G. Williams,
  • Stephanie L. Baross,
  • Yingjuan Liu,
  • Steven W. Wingett,
  • Artur Akbarov,
  • Chris Wallace,
  • Paula Freire-Pritchett,
  • Peter J. Rugg-Gunn,
  • Mikhail Spivakov,
  • Peter Fraser,
  • Bernard D. Keavney

DOI
https://doi.org/10.1038/s41467-018-04931-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with genetic loci associated with cardiac phenotypes.