The Basic Values of Intraocular Pressure Measured by Rebound Tonometry in Guinea Pig

Abstract

Elevated intraocular pressure (IOP) is the most important risk factor associated with the progression of glaucoma and the research on animal models is constantly evolving. Rebound tonometry has been shown to be useful for the evaluation of IOP, not only for the human patient but also for the animal patient. The aim of the paper is to assess intraocular pressure in guinea pigs in order to establish reference values. IOP was measured for three days, at different time intervals, in 40 guinea pigs, using the iCare Tonovet TV01 tonometer. The mean values obtained in coloured guinea pigs were 13.82 mmHg ± 1.64 mmHg in the right eye, 14.11 mmHg ± 1.68 mmHg in the left eye, and in white guinea pigs 12.56 mmHg ± 0.95 mmHg in the right eye, 13.02 mmHg ± 1.29 mmHg for the left eye. The values obtained from this study it can be concluded that the strain of coloured, records the highest values in the morning, which remain linear during the day, and decrease in the evening compared to the white strain which has a constant evolution during the day, and in the evening increases.

Keywords

• guinea pigs
• intraocular pressure
• rebound tonometry
• tonovet.