Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice

Abstract

Components of the seminal fluid are required for specific gene expression and immune changes in the uterus following mating, but the role that sperm play in this process has remained unclear. Here, John Schjenken et al. compare female mice mated to intact and vasectomized males and show that sperm are required for the full post-mating response, indicating a broader role for sperm in reproduction beyond fertilization.