Nature Communications (Nov 2019)
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
- Maria Andres-Alonso,
- Mohamed Raafet Ammar,
- Ioana Butnaru,
- Guilherme M. Gomes,
- Gustavo Acuña Sanhueza,
- Rajeev Raman,
- PingAn Yuanxiang,
- Maximilian Borgmeyer,
- Jeffrey Lopez-Rojas,
- Syed Ahsan Raza,
- Nicola Brice,
- Torben J. Hausrat,
- Tamar Macharadze,
- Silvia Diaz-Gonzalez,
- Mark Carlton,
- Antonio Virgilio Failla,
- Oliver Stork,
- Michaela Schweizer,
- Eckart D. Gundelfinger,
- Matthias Kneussel,
- Christina Spilker,
- Anna Karpova,
- Michael R. Kreutz
Affiliations
- Maria Andres-Alonso
- Leibniz Group ‘Dendritic Organelles and Synaptic Function’, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
- Mohamed Raafet Ammar
- RG Neuroplasticity, Leibniz Institute for Neurobiology
- Ioana Butnaru
- RG Neuroplasticity, Leibniz Institute for Neurobiology
- Guilherme M. Gomes
- RG Neuroplasticity, Leibniz Institute for Neurobiology
- Gustavo Acuña Sanhueza
- RG Neuroplasticity, Leibniz Institute for Neurobiology
- Rajeev Raman
- RG Neuroplasticity, Leibniz Institute for Neurobiology
- PingAn Yuanxiang
- RG Neuroplasticity, Leibniz Institute for Neurobiology
- Maximilian Borgmeyer
- Leibniz Group ‘Dendritic Organelles and Synaptic Function’, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
- Jeffrey Lopez-Rojas
- RG Neuroplasticity, Leibniz Institute for Neurobiology
- Syed Ahsan Raza
- Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University
- Nicola Brice
- Paradigm Therapeutics Ltd. Cambridge, UK Cerevance
- Torben J. Hausrat
- Institute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
- Tamar Macharadze
- RG Neuroplasticity, Leibniz Institute for Neurobiology
- Silvia Diaz-Gonzalez
- Leibniz Group ‘Dendritic Organelles and Synaptic Function’, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
- Mark Carlton
- Paradigm Therapeutics Ltd. Cambridge, UK Cerevance
- Antonio Virgilio Failla
- UKE Microscopy Imaging Facility, University Medical Center Hamburg-Eppendorf
- Oliver Stork
- Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University
- Michaela Schweizer
- ZMNH Core Facility Morphology and Electron Microscopy, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
- Eckart D. Gundelfinger
- Center for Behavioral Brain Sciences, Otto von Guericke University
- Matthias Kneussel
- Institute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
- Christina Spilker
- RG Neuroplasticity, Leibniz Institute for Neurobiology
- Anna Karpova
- RG Neuroplasticity, Leibniz Institute for Neurobiology
- Michael R. Kreutz
- Leibniz Group ‘Dendritic Organelles and Synaptic Function’, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-019-13224-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic boutons and that SIPA1L2, a member of the SIPA1L family of neuronal RapGAPs, associates via LC3b to TrkB-containing amphisomes to regulate its motility and signaling at the axon terminals
