Nature Communications (Aug 2019)
EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
- Roberta Ragazzini,
- Raquel Pérez-Palacios,
- Irem H. Baymaz,
- Seynabou Diop,
- Katia Ancelin,
- Dina Zielinski,
- Audrey Michaud,
- Maëlle Givelet,
- Mate Borsos,
- Setareh Aflaki,
- Patricia Legoix,
- Pascal W. T. C. Jansen,
- Nicolas Servant,
- Maria-Elena Torres-Padilla,
- Deborah Bourc’his,
- Pierre Fouchet,
- Michiel Vermeulen,
- Raphaël Margueron
Affiliations
- Roberta Ragazzini
- Institut Curie, PSL Research University, Sorbonne University, INSERM U934/ CNRS UMR3215
- Raquel Pérez-Palacios
- Institut Curie, PSL Research University, Sorbonne University, INSERM U934/ CNRS UMR3215
- Irem H. Baymaz
- Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen
- Seynabou Diop
- Institut Curie, PSL Research University, Sorbonne University, INSERM U934/ CNRS UMR3215
- Katia Ancelin
- Institut Curie, PSL Research University, Sorbonne University, INSERM U934/ CNRS UMR3215
- Dina Zielinski
- Institut Curie, PSL Research University, Sorbonne University, INSERM U934/ CNRS UMR3215
- Audrey Michaud
- Institut Curie, PSL Research University, Sorbonne University, INSERM U934/ CNRS UMR3215
- Maëlle Givelet
- Commissariat à l’énergie atomique et aux énergies alternatives, Institut de radiobiologie cellulaire et moléculaire, Laboratoire des Cellules Souches Germinales, INSERM U967
- Mate Borsos
- Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München
- Setareh Aflaki
- Institut Curie, PSL Research University, Sorbonne University, INSERM U934/ CNRS UMR3215
- Patricia Legoix
- ICGex Next-Generation Sequencing Platform, Curie Institute
- Pascal W. T. C. Jansen
- Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen
- Nicolas Servant
- Institut Curie, PSL Research University, Sorbonne University, INSERM U934/ CNRS UMR3215
- Maria-Elena Torres-Padilla
- Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München
- Deborah Bourc’his
- Institut Curie, PSL Research University, Sorbonne University, INSERM U934/ CNRS UMR3215
- Pierre Fouchet
- Commissariat à l’énergie atomique et aux énergies alternatives, Institut de radiobiologie cellulaire et moléculaire, Laboratoire des Cellules Souches Germinales, INSERM U967
- Michiel Vermeulen
- Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen
- Raphaël Margueron
- Institut Curie, PSL Research University, Sorbonne University, INSERM U934/ CNRS UMR3215
- DOI
- https://doi.org/10.1038/s41467-019-11800-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Polycomb Repressive Complex 2 (PRC2) plays critical roles in transcriptional silencing during development. Here the authors identify EZHIP as a cofactor of PRC2 expressed predominantly in the gonads, finding that EZHIP limits the enzymatic activity of PRC2 in germ cells in mice.
