Nature Communications (Apr 2019)
Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules
- Jason J. Paxman,
- Alvin W. Lo,
- Matthew J. Sullivan,
- Santosh Panjikar,
- Michael Kuiper,
- Andrew E. Whitten,
- Geqing Wang,
- Chi-Hao Luan,
- Danilo G. Moriel,
- Lendl Tan,
- Kate M. Peters,
- Minh-Duy Phan,
- Christine L. Gee,
- Glen C. Ulett,
- Mark A. Schembri,
- Begoña Heras
Affiliations
- Jason J. Paxman
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Alvin W. Lo
- School of Chemistry and Molecular Biosciences, and Australian Infectious Diseases Research Centre, The University of Queensland
- Matthew J. Sullivan
- School of Medical Science, and Menzies Health Institute Queensland, Griffith University
- Santosh Panjikar
- Macromolecular Crystallography, Australian Synchrotron
- Michael Kuiper
- Molecular & Materials Modelling group Data61, CSIRO
- Andrew E. Whitten
- Australian Centre for Neutron Scattering, Australian Nuclear Science and Technology Organisation
- Geqing Wang
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Chi-Hao Luan
- High Throughput Analysis Laboratory and Department of Molecular Biosciences, Northwestern University
- Danilo G. Moriel
- School of Chemistry and Molecular Biosciences, and Australian Infectious Diseases Research Centre, The University of Queensland
- Lendl Tan
- School of Chemistry and Molecular Biosciences, and Australian Infectious Diseases Research Centre, The University of Queensland
- Kate M. Peters
- School of Chemistry and Molecular Biosciences, and Australian Infectious Diseases Research Centre, The University of Queensland
- Minh-Duy Phan
- School of Chemistry and Molecular Biosciences, and Australian Infectious Diseases Research Centre, The University of Queensland
- Christine L. Gee
- Macromolecular Crystallography, Australian Synchrotron
- Glen C. Ulett
- School of Medical Science, and Menzies Health Institute Queensland, Griffith University
- Mark A. Schembri
- School of Chemistry and Molecular Biosciences, and Australian Infectious Diseases Research Centre, The University of Queensland
- Begoña Heras
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- DOI
- https://doi.org/10.1038/s41467-019-09814-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Autotransporter proteins are localised to the bacterial surface and promote colonisation of host epithelial surfaces. Here, the authors present the crystal structure of autotransporter UpaB and show evidence for distinct binding sites for glycosaminoglycans and host fibronectin.
