Nature Communications (Nov 2018)
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
- Joshua Moss,
- Judith Magenheim,
- Daniel Neiman,
- Hai Zemmour,
- Netanel Loyfer,
- Amit Korach,
- Yaacov Samet,
- Myriam Maoz,
- Henrik Druid,
- Peter Arner,
- Keng-Yeh Fu,
- Endre Kiss,
- Kirsty L. Spalding,
- Giora Landesberg,
- Aviad Zick,
- Albert Grinshpun,
- A. M. James Shapiro,
- Markus Grompe,
- Avigail Dreazan Wittenberg,
- Benjamin Glaser,
- Ruth Shemer,
- Tommy Kaplan,
- Yuval Dor
Affiliations
- Joshua Moss
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
- Judith Magenheim
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
- Daniel Neiman
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
- Hai Zemmour
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
- Netanel Loyfer
- School of Computer Science and Engineering, The Hebrew University of Jerusalem
- Amit Korach
- Department of Cardio-Thoracic Surgery, Hadassah-Hebrew University Medical Center
- Yaacov Samet
- Department of Vascular Surgery, Hadassah-Hebrew University Medical Center
- Myriam Maoz
- Department of Oncology, Hadassah-Hebrew University Medical Center
- Henrik Druid
- Department of Oncology-Pathology, Karolinska Institutet
- Peter Arner
- Department of Medicine, Karolinska University Hospital, Karolinska Institutet
- Keng-Yeh Fu
- Department of Cell and Molecular Biology, Karolinska Institutet
- Endre Kiss
- Department of Cell and Molecular Biology, Karolinska Institutet
- Kirsty L. Spalding
- Department of Medicine, Karolinska University Hospital, Karolinska Institutet
- Giora Landesberg
- Dept of Anesthesiology and Critical Care Medicine, Hadassah-Hebrew University Medical Center
- Aviad Zick
- Department of Oncology, Hadassah-Hebrew University Medical Center
- Albert Grinshpun
- Department of Oncology, Hadassah-Hebrew University Medical Center
- A. M. James Shapiro
- Department of Surgery and the Clinical Islet Transplant Program, University of Alberta
- Markus Grompe
- Papé Family Pediatric Research Institute, Oregon Health & Science University
- Avigail Dreazan Wittenberg
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
- Benjamin Glaser
- Dept of Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center
- Ruth Shemer
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
- Tommy Kaplan
- School of Computer Science and Engineering, The Hebrew University of Jerusalem
- Yuval Dor
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School
- DOI
- https://doi.org/10.1038/s41467-018-07466-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reveals tissue contributions that agree with clinical findings.
