Nature Communications (Dec 2020)
Common germline-somatic variant interactions in advanced urothelial cancer
- Aram Vosoughi,
- Tuo Zhang,
- Kyrillus S. Shohdy,
- Panagiotis J. Vlachostergios,
- David C. Wilkes,
- Bhavneet Bhinder,
- Scott T. Tagawa,
- David M. Nanus,
- Ana M. Molina,
- Himisha Beltran,
- Cora N. Sternberg,
- Samaneh Motanagh,
- Brian D. Robinson,
- Jenny Xiang,
- Xiao Fan,
- Wendy K. Chung,
- Mark A. Rubin,
- Olivier Elemento,
- Andrea Sboner,
- Juan Miguel Mosquera,
- Bishoy M. Faltas
Affiliations
- Aram Vosoughi
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Tuo Zhang
- Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine-New York-Presbyterian Hospital
- Kyrillus S. Shohdy
- Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine
- Panagiotis J. Vlachostergios
- Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine
- David C. Wilkes
- Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine-New York-Presbyterian Hospital
- Bhavneet Bhinder
- Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine-New York-Presbyterian Hospital
- Scott T. Tagawa
- Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine
- David M. Nanus
- Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine
- Ana M. Molina
- Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine
- Himisha Beltran
- Division of Medical Oncology, Dana Farber Cancer Institute
- Cora N. Sternberg
- Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine
- Samaneh Motanagh
- Department of Pathology, Dartmouth–Hitchcock Medical Center
- Brian D. Robinson
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Jenny Xiang
- Genomic Resources Core Facility, Weill Cornell Medicine
- Xiao Fan
- Departments of Pediatrics and Medicine, Columbia University, NY
- Wendy K. Chung
- Departments of Pediatrics and Medicine, Columbia University, NY
- Mark A. Rubin
- Department for Biomedical Research, University of Bern
- Olivier Elemento
- Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine-New York-Presbyterian Hospital
- Andrea Sboner
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Juan Miguel Mosquera
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Bishoy M. Faltas
- Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine-New York-Presbyterian Hospital
- DOI
- https://doi.org/10.1038/s41467-020-19971-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
The role of germline variation in human cancers is not fully understood. Here, the authors define the landscape of putative deleterious germline variants that abrogate tumor suppressor proteins in advanced urothelial cancer patients.
