Noncontrast MRI with advanced diffusion weighted imaging for breast cancer detection in a lactating woman

Ana E. Rodríguez-Soto, PhD; Claire H. Meriwether, MD; Andrew J. Park, MD; Dennis W. Adams Jr, MD; Anne Wallace, MD; Haydee Ojeda-Fournier, MD; Anders M. Dale, PhD; Rebecca Rakow-Penner, MD, PhD

Radiology Case Reports (Nov 2020)

Noncontrast MRI with advanced diffusion weighted imaging for breast cancer detection in a lactating woman

Ana E. Rodríguez-Soto, PhD,
Claire H. Meriwether, MD,
Andrew J. Park, MD,
Dennis W. Adams Jr, MD,
Anne Wallace, MD,
Haydee Ojeda-Fournier, MD,
Anders M. Dale, PhD,
Rebecca Rakow-Penner, MD, PhD

Affiliations

Ana E. Rodríguez-Soto, PhD: Department of Radiology, University of California, San Diego. La Jolla, CA, USA
Claire H. Meriwether, MD: School of Medicine, University of California, San Diego. La Jolla, CA, USA
Andrew J. Park, MD: Department of Pathology, University of California, San Diego. La Jolla, CA, USA
Dennis W. Adams Jr, MD: Department of Pathology, University of California, San Diego. La Jolla, CA, USA
Anne Wallace, MD: Department of Surgery, University of California, San Diego. La Jolla, CA, USA
Haydee Ojeda-Fournier, MD: Department of Radiology, University of California, San Diego. La Jolla, CA, USA
Anders M. Dale, PhD: Department of Radiology, University of California, San Diego. La Jolla, CA, USA
Rebecca Rakow-Penner, MD, PhD: Department of Radiology, University of California, San Diego. La Jolla, CA, USA; Corresponding author.

Journal volume & issue: Vol. 15, no. 11
pp. 2358 – 2361

Abstract

Read online

Magnetic resonance imaging (MRI) is used for preoperative evaluation, high-risk screening, and other select indications for breast cancer. However, the interpretation of breast MR images in pregnant and lactating women is complicated by physiologic changes of the breast that may result in marked background enhancement. Breast MRI with contrast administration is contraindicated in pregnancy. Restriction spectrum imaging (RSI) is an advanced diffusion-weighted (DW)-MRI method that theoretically reflects signal from cells with high nuclear-to-cytoplasm ratio without gadolinium-based contrast. This report describes a case in which RSI notably increased tumor conspicuity in a lactating woman, compared to contrast-enhanced (CE)-MRI and conventional DW-MRI.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

About the journal

Abstract

Keywords