Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents

Saché M. Coury; Vanessa López; Zia Bajwa; Jordan M. Garcia; Giana I. Teresi; Kate R. Kuhlman; Yan Li; Steve Cole; David J. Miklowitz; Ioannis Pappas; Tiffany C. Ho

Brain, Behavior, & Immunity - Health (Feb 2024)

Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents

Saché M. Coury,
Vanessa López,
Zia Bajwa,
Jordan M. Garcia,
Giana I. Teresi,
Kate R. Kuhlman,
Yan Li,
Steve Cole,
David J. Miklowitz,
Ioannis Pappas,
Tiffany C. Ho

Affiliations

Saché M. Coury: Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
Vanessa López: Department of Neuroscience, Columbia University, New York, NY, USA
Zia Bajwa: Department of Psychiatry, Columnia University, New York, NY, USA
Jordan M. Garcia: School of Social Work, University of Washington, Seattle, WA, USA
Giana I. Teresi: Department of Psychology, University of Pittsburgh, Pittsburgh, USA
Kate R. Kuhlman: Department of Psychological Science, School of Social Ecology, University of California Irvine, Irvine, CA, USA; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA
Yan Li: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
Steve Cole: Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA; Departments of Psychiatry and Biobehavioral Sciences and Medicine, Division of Hematology-Oncology, University of California Los Angeles, Los Angeles, CA 90095, USA
David J. Miklowitz: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
Ioannis Pappas: Laboratory of NeuroImaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Tiffany C. Ho: Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA; Corresponding author.Department of Psychology University of California, 502 Portola Plaza Los Angeles, CA 90095, USA

Journal volume & issue: Vol. 35
p. 100718

Abstract

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Adolescent-onset depression is a prevalent and debilitating condition commonly associated with treatment refractory depression and non-response to first-line antidepressants. There are, however, no objective tests to determine who may or may not respond to antidepressants. As depressed adolescents are especially vulnerable to the lifelong consequences of ineffectively-treated depression, it is critical to identify neurobiological predictors of treatment non-response in this population. Here, we describe the scientific rationale and protocol for the Teen Inflammation Glutamate Emotion Research (TIGER) study, a prospective 18-month investigation of 160 depressed adolescents who will be assessed before and after treatment with selective serotonin reuptake inhibitors. TIGER will be using ultra-high field imaging to test the effects of acute stress and antidepressant treatment on inflammatory and glutamatergic processes hypothesized to underlie depression maintenance. Results from this work will motivate future studies testing alternative therapeutics for depressed adolescents at risk for treatment resistant depression. ClinicalTrials.gov Identifier: NCT05329441.

Published in Brain, Behavior, & Immunity - Health

ISSN: 2666-3546 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/brain-behavior-and-immunity-health

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