Nature Communications (Mar 2018)
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors
- Michele Vigolo,
- Melissa G. Chambers,
- Laure Willen,
- Dehlia Chevalley,
- Klaus Maskos,
- Alfred Lammens,
- Aubry Tardivel,
- Dolon Das,
- Christine Kowalczyk-Quintas,
- Sonia Schuepbach-Mallepell,
- Cristian R. Smulski,
- Mahya Eslami,
- Antonius Rolink,
- Edith Hummler,
- Eileen Samy,
- Yves Fomekong Nanfack,
- Fabienne Mackay,
- Maofu Liao,
- Henry Hess,
- Xuliang Jiang,
- Pascal Schneider
Affiliations
- Michele Vigolo
- Department of Biochemistry, University of Lausanne
- Melissa G. Chambers
- Department of Cell Biology, Harvard Medical School
- Laure Willen
- Department of Biochemistry, University of Lausanne
- Dehlia Chevalley
- Department of Biochemistry, University of Lausanne
- Klaus Maskos
- Proteros Biostructures GmbH
- Alfred Lammens
- Proteros Biostructures GmbH
- Aubry Tardivel
- Department of Biochemistry, University of Lausanne
- Dolon Das
- Department of Biochemistry, University of Lausanne
- Christine Kowalczyk-Quintas
- Department of Biochemistry, University of Lausanne
- Sonia Schuepbach-Mallepell
- Department of Biochemistry, University of Lausanne
- Cristian R. Smulski
- Department of Biochemistry, University of Lausanne
- Mahya Eslami
- Department of Biochemistry, University of Lausanne
- Antonius Rolink
- Department of Biomedicine, University of Basel
- Edith Hummler
- Department of Pharmacology and Toxicology, University of Lausanne
- Eileen Samy
- EMD Serono Research & Development Institute
- Yves Fomekong Nanfack
- EMD Serono Research & Development Institute
- Fabienne Mackay
- Department of Immunology, Monash University
- Maofu Liao
- Department of Cell Biology, Harvard Medical School
- Henry Hess
- Merck KGaA
- Xuliang Jiang
- EMD Serono Research & Development Institute
- Pascal Schneider
- Department of Biochemistry, University of Lausanne
- DOI
- https://doi.org/10.1038/s41467-018-03323-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
BAFF is an important cytokine for B cell survival, and is a therapeutic target for autoimmune disorders. Here the authors show that a 'flap' region of BAFF converts BAFFR binding events into survival signals and, with structural data, that this ‘flap’ differentially modulates binding of drugs such as belimumab or atacicept.
