Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens

Verena Klemis; Tina Schmidt; David Schub; Janine Mihm; Stefanie Marx; Amina Abu-Omar; Laura Ziegler; Franziska Hielscher; Candida Guckelmus; Rebecca Urschel; Stefan Wagenpfeil; Sophie Schneitler; Sören L. Becker; Barbara C. Gärtner; Urban Sester; Martina Sester

doi:10.1038/s41467-022-32321-0

Nature Communications (Aug 2022)

Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens

Verena Klemis,
Tina Schmidt,
David Schub,
Janine Mihm,
Stefanie Marx,
Amina Abu-Omar,
Laura Ziegler,
Franziska Hielscher,
Candida Guckelmus,
Rebecca Urschel,
Stefan Wagenpfeil,
Sophie Schneitler,
Sören L. Becker,
Barbara C. Gärtner,
Urban Sester,
Martina Sester

Affiliations

Verena Klemis: Department of Transplant and Infection Immunology, Saarland University
Tina Schmidt: Department of Transplant and Infection Immunology, Saarland University
David Schub: Department of Transplant and Infection Immunology, Saarland University
Janine Mihm: Department of Internal Medicine IV, Saarland University
Stefanie Marx: Department of Transplant and Infection Immunology, Saarland University
Amina Abu-Omar: Department of Transplant and Infection Immunology, Saarland University
Laura Ziegler: Department of Transplant and Infection Immunology, Saarland University
Franziska Hielscher: Department of Transplant and Infection Immunology, Saarland University
Candida Guckelmus: Department of Transplant and Infection Immunology, Saarland University
Rebecca Urschel: Department of Transplant and Infection Immunology, Saarland University
Stefan Wagenpfeil: Institute for Medical Statistics, Epidemiology and Medical Informatics, Saarland University, Campus Homburg/Saar
Sophie Schneitler: Institute of Medical Microbiology and Hygiene, Saarland University
Sören L. Becker: Institute of Medical Microbiology and Hygiene, Saarland University
Barbara C. Gärtner: Institute of Medical Microbiology and Hygiene, Saarland University
Urban Sester: Department of Internal Medicine IV, Saarland University
Martina Sester: Department of Transplant and Infection Immunology, Saarland University

DOI: https://doi.org/10.1038/s41467-022-32321-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Multiple formulations and technologies for vaccinating against SARS-CoV-2 exist but how the use of these in homologous or heterologous format impacts immunogenicity is far from clear. Here the authors compare a range of heterologous and homologous SARS-CoV-2 vaccination strategies and assess the induced humoral and cellular immune response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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