Strategies for the study of neuroepigenetics and aging with a translational approach

Abstract

Summary: The study of the biological mechanisms of aging is central to increasing knowledge about the susceptibility to the development of diseases associated with advanced age. The advancement of technology has allowed a greater understanding of the intracellular networks that can influence the progression of neurodegenerative diseases. Nevertheless, comprehensive knowledge of the experimental and clinical approaches that impact public health is still needed. The study of the interconnection of the biological components that lead to the development of neurodegenerative diseases should focus on a translational approach that aids in understanding the interindividual differences in terms of the epigenetic characteristics of aging. Therefore, this article discusses the advances in knowledge of the neuroepigenetics of aging and the opportunity to link them to clinical knowledge from a translational approach.

Keywords

• Neuroepigenetics
• Aging
• Methylation
• Translational