HIV-1 DNA sequence diversity and evolution during acute subtype C infection

Guinevere Q. Lee; Kavidha Reddy; Kevin B. Einkauf; Kamini Gounder; Joshua M. Chevalier; Krista L. Dong; Bruce D. Walker; Xu G. Yu; Thumbi Ndung’u; Mathias Lichterfeld

doi:10.1038/s41467-019-10659-2

Nature Communications (Jun 2019)

HIV-1 DNA sequence diversity and evolution during acute subtype C infection

Guinevere Q. Lee,
Kavidha Reddy,
Kevin B. Einkauf,
Kamini Gounder,
Joshua M. Chevalier,
Krista L. Dong,
Bruce D. Walker,
Xu G. Yu,
Thumbi Ndung’u,
Mathias Lichterfeld

Affiliations

Guinevere Q. Lee: Ragon Institute of MGH, MIT and Harvard
Kavidha Reddy: HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal
Kevin B. Einkauf: Ragon Institute of MGH, MIT and Harvard
Kamini Gounder: HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal
Joshua M. Chevalier: Ragon Institute of MGH, MIT and Harvard
Krista L. Dong: Ragon Institute of MGH, MIT and Harvard
Bruce D. Walker: Ragon Institute of MGH, MIT and Harvard
Xu G. Yu: Ragon Institute of MGH, MIT and Harvard
Thumbi Ndung’u: Ragon Institute of MGH, MIT and Harvard
Mathias Lichterfeld: Ragon Institute of MGH, MIT and Harvard

DOI: https://doi.org/10.1038/s41467-019-10659-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

The dynamics of HIV-1 DNA sequences early after HIV-1 transmission remains poorly characterized. Here, the authors perform a longitudinal evaluation of HIV-1 DNA sequences in subtype C-infected individuals during acute infection, providing a landscape of the nature and evolution of the very early viral genome.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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