Association between Mean Platelet Volume and Bone Mineral Density in Rheumatoid Arthritis

Abstract

Introduction:This study aimed to evaluate the mean platelet volume (MPV) levels in rheumatoid arthritis (RA) and determine whether there is a relationship between MPV and bone mineral density (BMD) measurement.Methods:A total of 108 RA patients [31 osteopenia, 45 osteoporosis (OP), and 32 normal BMD] were included in the study. The age, gender, body weight, height, body mass index, MPV, calcium and vitamin D levels, and BMD scores were recorded.Results:The mean age was 50.20±5.5 years. The mean levels of MPV were 10.70, 11.00, and 10.55 fL in the osteopenic, osteoporotic, and normal groups, respectively. The median weight and femoral neck T-score of the osteoporotic group were different from other groups. The median lumbar 1-4 T-score of all groups was different from each other. We found a negative correlation between MPV and femoral neck T-score.Conclusion:Our study is the first to assess MPV levels in normal, osteopenic, and osteoporotic RA patients. However, we did not find similar results when the mean platelet levels of all three groups were compared. The correlation analysis showed that MPV elevation may be related to OP in the differential diagnosis for patients with RA.

Keywords

• bone mineral density
• mean platelet volume
• rheumatoid arthritis