Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes

Shuhei Yoshida; Sui Nishiyama; Lisa Lister; Shu Hashimoto; Tappei Mishina; Aurélien Courtois; Hirohisa Kyogoku; Takaya Abe; Aki Shiraishi; Meenakshi Choudhary; Yoshiharu Nakaoka; Mary Herbert; Tomoya S. Kitajima

doi:10.1038/s41467-020-16488-y

Nature Communications (May 2020)

Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes

Shuhei Yoshida,
Sui Nishiyama,
Lisa Lister,
Shu Hashimoto,
Tappei Mishina,
Aurélien Courtois,
Hirohisa Kyogoku,
Takaya Abe,
Aki Shiraishi,
Meenakshi Choudhary,
Yoshiharu Nakaoka,
Mary Herbert,
Tomoya S. Kitajima

Affiliations

Shuhei Yoshida: Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)
Sui Nishiyama: Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)
Lisa Lister: Biosciences Institute, Newcastle University, Centre for Life, Times Square
Shu Hashimoto: Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)
Tappei Mishina: Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)
Aurélien Courtois: Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)
Hirohisa Kyogoku: Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)
Takaya Abe: Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research (BDR)
Aki Shiraishi: Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research (BDR)
Meenakshi Choudhary: Biosciences Institute, Newcastle University, Centre for Life, Times Square
Yoshiharu Nakaoka: IVF Namba Clinic
Mary Herbert: Biosciences Institute, Newcastle University, Centre for Life, Times Square
Tomoya S. Kitajima: Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)

DOI: https://doi.org/10.1038/s41467-020-16488-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Oocyte meiosis must achieve spindle bipolarization without predefined spatial cues. Yoshida et al. demonstrate that spindle bipolarization during meiosis I in mouse oocytes requires kinetochores to prevent chromosome segregation errors, a phenomenon that does not occur in error-prone human oocytes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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