Nature Communications (Sep 2021)
C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
- Hitoki Nanaura,
- Honoka Kawamukai,
- Ayano Fujiwara,
- Takeru Uehara,
- Yuichiro Aiba,
- Mari Nakanishi,
- Tomo Shiota,
- Masaki Hibino,
- Pattama Wiriyasermkul,
- Sotaro Kikuchi,
- Riko Nagata,
- Masaya Matsubayashi,
- Yoichi Shinkai,
- Tatsuya Niwa,
- Taro Mannen,
- Naritaka Morikawa,
- Naohiko Iguchi,
- Takao Kiriyama,
- Ken Morishima,
- Rintaro Inoue,
- Masaaki Sugiyama,
- Takashi Oda,
- Noriyuki Kodera,
- Sachiko Toma-Fukai,
- Mamoru Sato,
- Hideki Taguchi,
- Shushi Nagamori,
- Osami Shoji,
- Koichiro Ishimori,
- Hiroyoshi Matsumura,
- Kazuma Sugie,
- Tomohide Saio,
- Takuya Yoshizawa,
- Eiichiro Mori
Affiliations
- Hitoki Nanaura
- Department of Neurology, Nara Medical University
- Honoka Kawamukai
- Graduate School of Chemical Sciences and Engineering, Hokkaido University
- Ayano Fujiwara
- College of Life Sciences, Ritsumeikan University
- Takeru Uehara
- College of Life Sciences, Ritsumeikan University
- Yuichiro Aiba
- Department of Chemistry, Graduate School of Science, Nagoya University
- Mari Nakanishi
- Department of Future Basic Medicine, Nara Medical University
- Tomo Shiota
- Department of Neurology, Nara Medical University
- Masaki Hibino
- Department of Chemistry, Graduate School of Science, Nagoya University
- Pattama Wiriyasermkul
- Laboratory of Bio-Molecular Dynamics, Department of Collaborative Research, Nara Medical University
- Sotaro Kikuchi
- Department of Future Basic Medicine, Nara Medical University
- Riko Nagata
- Department of Future Basic Medicine, Nara Medical University
- Masaya Matsubayashi
- Department of Future Basic Medicine, Nara Medical University
- Yoichi Shinkai
- Molecular Neurobiology Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
- Tatsuya Niwa
- Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
- Taro Mannen
- College of Life Sciences, Ritsumeikan University
- Naritaka Morikawa
- Department of Future Basic Medicine, Nara Medical University
- Naohiko Iguchi
- Department of Neurology, Nara Medical University
- Takao Kiriyama
- Department of Neurology, Nara Medical University
- Ken Morishima
- Institute for Integrated Radiation and Nuclear Science, Kyoto University
- Rintaro Inoue
- Institute for Integrated Radiation and Nuclear Science, Kyoto University
- Masaaki Sugiyama
- Institute for Integrated Radiation and Nuclear Science, Kyoto University
- Takashi Oda
- Graduate School of Medical Life Science, Yokohama City University
- Noriyuki Kodera
- Nano Life Science Institute (WPI-NanoLSI), Kanazawa University
- Sachiko Toma-Fukai
- Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology
- Mamoru Sato
- Graduate School of Medical Life Science, Yokohama City University
- Hideki Taguchi
- Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
- Shushi Nagamori
- Laboratory of Bio-Molecular Dynamics, Department of Collaborative Research, Nara Medical University
- Osami Shoji
- Department of Chemistry, Graduate School of Science, Nagoya University
- Koichiro Ishimori
- Graduate School of Chemical Sciences and Engineering, Hokkaido University
- Hiroyoshi Matsumura
- College of Life Sciences, Ritsumeikan University
- Kazuma Sugie
- Department of Neurology, Nara Medical University
- Tomohide Saio
- Graduate School of Medical Sciences, Tokushima University
- Takuya Yoshizawa
- College of Life Sciences, Ritsumeikan University
- Eiichiro Mori
- Department of Future Basic Medicine, Nara Medical University
- DOI
- https://doi.org/10.1038/s41467-021-25560-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Nuclear import receptors (NIRs) regulate self-association of RNA-binding proteins as phase modifiers, while C9orf72-derived arginine-rich polydipeptides lead to aberrant phase transitions. Here the authors show in molecular basis how arginine-rich poly-dipeptides impede the ability of NIRs, particularly Kapβ2.
