Biological Evaluation of Arylamine Mannich Base Derivatives with Potent In Vivo Activity as Potent Antichagasic Agents

Affiliations

Rocio Paucar-Bernabé: Department of Organic and Pharmaceutical Chemistry, Institute of Tropical Health, Universidad de Navarra, 31008 Pamplona, Spain
Elsa Moreno-Viguri: Department of Organic and Pharmaceutical Chemistry, Institute of Tropical Health, Universidad de Navarra, 31008 Pamplona, Spain
Rubén Martín-Escolano: Departamento de Parasitología, Instituto de Investigación Biosanitaria (ibs.GRANADA), Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, Spain
Mery Santivañez-Veliz: Department of Organic and Pharmaceutical Chemistry, Institute of Tropical Health, Universidad de Navarra, 31008 Pamplona, Spain
Amaya Azqueta: Department of Pharmacology and Toxicology, Universidad de Navarra, Pamplona 31008, Spain
Nuria Cirauqui: Department of Pharmaceutical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21949-900, Brazil
Manuel Sánchez-Moreno: Departamento de Parasitología, Instituto de Investigación Biosanitaria (ibs.GRANADA), Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, Spain
Silvia Pérez-Silanes: Department of Organic and Pharmaceutical Chemistry, Institute of Tropical Health, Universidad de Navarra, 31008 Pamplona, Spain

Abstract

Chagas disease (CD) is a neglected tropical disease caused by the parasite Trypanosoma cruzi [1]. [...]