Frontiers in Immunology (Nov 2021)

Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers

  • Ziwen Zhong,
  • Ziwen Zhong,
  • Ke Nan,
  • Meilin Weng,
  • Ying Yue,
  • Wenchang Zhou,
  • Zhiqiang Wang,
  • Yiwei Chu,
  • Yiwei Chu,
  • Ronghua Liu,
  • Changhong Miao

DOI
https://doi.org/10.3389/fimmu.2021.765044
Journal volume & issue
Vol. 12

Abstract

Read online

B cells are well known as key mediators of humoral immune responses via the production of antibodies. Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and provides the first line of immune protection at mucosal surfaces. However, IgA has long been a divisive molecule with respect to tumor progression. IgA exerts anti- or pro-tumor effect in different tumor types. In this review, we summarize emerging evidence regarding the production and effects of IgA and IgA+ cells in the tumor microenvironment (TME). Moreover, we discuss that the TME cytokines, host diet, microbiome, and metabolites play a pivotal role in controlling the class-switch recombination (CSR) of IgA. The analysis of intratumoral Ig repertoires and determination of metabolites that influence CSR may help establish novel therapeutic targets for the treatment of cancers.

Keywords