A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

Jian Zhang; Yongjun Zheng; Jimmy Lee; Jieyu Hua; Shilong Li; Ananth Panchamukhi; Jiping Yue; Xuewen Gou; Zhaofan Xia; Linyong Zhu; Xiaoyang Wu

doi:10.1038/s41467-021-21964-0

Nature Communications (Mar 2021)

A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

Jian Zhang,
Yongjun Zheng,
Jimmy Lee,
Jieyu Hua,
Shilong Li,
Ananth Panchamukhi,
Jiping Yue,
Xuewen Gou,
Zhaofan Xia,
Linyong Zhu,
Xiaoyang Wu

Affiliations

Jian Zhang: The University of Chicago, Ben May Department for Cancer Research
Yongjun Zheng: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & Technology
Jimmy Lee: The University of Chicago, Ben May Department for Cancer Research
Jieyu Hua: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & Technology
Shilong Li: The University of Chicago, Ben May Department for Cancer Research
Ananth Panchamukhi: The University of Chicago, Ben May Department for Cancer Research
Jiping Yue: The University of Chicago, Ben May Department for Cancer Research
Xuewen Gou: The University of Chicago, Ben May Department for Cancer Research
Zhaofan Xia: Burns Center of Changhai Hospital
Linyong Zhu: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & Technology
Xiaoyang Wu: The University of Chicago, Ben May Department for Cancer Research

DOI: https://doi.org/10.1038/s41467-021-21964-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Dysfunctional and disfiguring scars can result from aberrant wound repair. Here, the authors develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for scarless wound repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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