Guoji Yanke Zazhi (Sep 2018)

Early multifocal electroretinography findings after intravitreal Conbercept in the treatment of wet age-related macular degeneration

  • Ding-Guo Huang,
  • Jian-Long Zheng,
  • Guo-Qiao Lin,
  • Wei-Qi Chen

DOI
https://doi.org/10.3980/j.issn.1672-5123.2018.9.31
Journal volume & issue
Vol. 18, no. 9
pp. 1692 – 1695

Abstract

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AIM: To evaluate the early changes of retinal function in patients with wet age-related macular degeneration(ARMD)after intravitreal Conbercept treatment by multifocal electroretinography(mfERG). METHODS: Wet ARMD patients diagnosed by fundus fluorescein angiography and received intravitreal injection of Conbercept(0.05mL/0.5mg)were included. Best corrected visual acuity(BCVA), incubation of N1, P1 and amplitude of P1 in mfERG test were recorded before and 1mo after treatment. RESULTS: Twenty patients(20 eyes)were enrolled in total. The mean BCVA was 0.80±0.48 LogMAR at baseline and improved to 0.65±0.50 LogMAR after treatment(P2 to 53.81±20.41nV/deg2(P=0.006). The change in visual acuity was positively correlated with the change in P1 amplitude density of Ring 1(r=-0.776, PCONCLUSION: Intravitreal conbercept injection can improve the central retinal function of wet ARMD patients in the short term.

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