mSphere (Aug 2021)
Sex Disparities and Neutralizing-Antibody Durability to SARS-CoV-2 Infection in Convalescent Individuals
- Alena J. Markmann,
- Natasa Giallourou,
- D. Ryan Bhowmik,
- Yixuan J. Hou,
- Aaron Lerner,
- David R. Martinez,
- Lakshmanane Premkumar,
- Heather Root,
- David van Duin,
- Sonia Napravnik,
- Stephen D. Graham,
- Quique Guerra,
- Rajendra Raut,
- Christos J. Petropoulos,
- Terri Wrin,
- Caleb Cornaby,
- John Schmitz,
- JoAnn Kuruc,
- Susan Weiss,
- Yara Park,
- Ralph Baric,
- Aravinda M. de Silva,
- David M. Margolis,
- Luther A. Bartelt
Affiliations
- Alena J. Markmann
- ORCiD
- Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Natasa Giallourou
- Centre of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus, Nicosia, Cyprus
- D. Ryan Bhowmik
- Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Yixuan J. Hou
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
- Aaron Lerner
- Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- David R. Martinez
- Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
- Lakshmanane Premkumar
- Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Heather Root
- Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- David van Duin
- Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Sonia Napravnik
- Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Stephen D. Graham
- Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Quique Guerra
- Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Rajendra Raut
- Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Christos J. Petropoulos
- LabCorp-Monogram Biosciences, South San Francisco, California, USA
- Terri Wrin
- LabCorp-Monogram Biosciences, South San Francisco, California, USA
- Caleb Cornaby
- Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- John Schmitz
- ORCiD
- Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- JoAnn Kuruc
- Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Susan Weiss
- Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Yara Park
- Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Ralph Baric
- ORCiD
- Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Aravinda M. de Silva
- Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- David M. Margolis
- Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- Luther A. Bartelt
- Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- DOI
- https://doi.org/10.1128/mSphere.00275-21
- Journal volume & issue
-
Vol. 6,
no. 4
Abstract
In this study, we found that neutralizing antibody responses in COVID-19-convalescent individuals vary in magnitude but are durable and correlate well with receptor binding domain (RBD) Ig binding antibody levels compared to other SARS-CoV-2 antigen responses. In our cohort, higher neutralizing antibody titers are independently and significantly associated with male sex compared to female sex.
