Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window

Wanjie Wu; Sicong He; Junqiang Wu; Congping Chen; Xuesong Li; Kai Liu; Jianan Y. Qu

doi:10.1038/s41467-022-29496-x

Nature Communications (Apr 2022)

Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window

Wanjie Wu,
Sicong He,
Junqiang Wu,
Congping Chen,
Xuesong Li,
Kai Liu,
Jianan Y. Qu

Affiliations

Wanjie Wu: Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology
Sicong He: Department of Biology, School of Life Sciences, Southern University of Science and Technology
Junqiang Wu: Division of Life Science, The Hong Kong University of Science and Technology
Congping Chen: Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology
Xuesong Li: Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology
Kai Liu: Division of Life Science, The Hong Kong University of Science and Technology
Jianan Y. Qu: Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-29496-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

Wu et al. developed a technique for longitudinal imaging with subcellular resolution of the spinal cord without causing inflammation or microglia activation in live mouse through an optically cleared intervertebral window.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal