Frontiers in Pharmacology (Dec 2023)

Decoding signaling mechanisms: unraveling the targets of guanylate cyclase agonists in cardiovascular and digestive diseases

  • Qinan Yin,
  • Qinan Yin,
  • Xingyue Zheng,
  • Xingyue Zheng,
  • Yujie Song,
  • Yujie Song,
  • Liuyun Wu,
  • Liuyun Wu,
  • Lian Li,
  • Lian Li,
  • Rongsheng Tong,
  • Rongsheng Tong,
  • Lizhu Han,
  • Lizhu Han,
  • Yuan Bian,
  • Yuan Bian

DOI
https://doi.org/10.3389/fphar.2023.1272073
Journal volume & issue
Vol. 14

Abstract

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Soluble guanylate cyclase agonists and guanylate cyclase C agonists are two popular drugs for diseases of the cardiovascular system and digestive systems. The common denominator in these conditions is the potential therapeutic target of guanylate cyclase. Thanks to in-depth explorations of their underlying signaling mechanisms, the targets of these drugs are becoming clearer. This review explains the recent research progress regarding potential drugs in this class by introducing representative drugs and current findings on them.

Keywords