Nature Communications (Dec 2019)
Edematous severe acute malnutrition is characterized by hypomethylation of DNA
- Katharina V. Schulze,
- Shanker Swaminathan,
- Sharon Howell,
- Aarti Jajoo,
- Natasha C. Lie,
- Orgen Brown,
- Roa Sadat,
- Nancy Hall,
- Liang Zhao,
- Kwesi Marshall,
- Thaddaeus May,
- Marvin E. Reid,
- Carolyn Taylor-Bryan,
- Xueqing Wang,
- John W. Belmont,
- Yongtao Guan,
- Mark J. Manary,
- Indi Trehan,
- Colin A. McKenzie,
- Neil A. Hanchard
Affiliations
- Katharina V. Schulze
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Shanker Swaminathan
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Sharon Howell
- Tropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies
- Aarti Jajoo
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Natasha C. Lie
- USDA/ARS/Children’s Nutrition Research Center, Baylor College of Medicine
- Orgen Brown
- Tropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies
- Roa Sadat
- USDA/ARS/Children’s Nutrition Research Center, Baylor College of Medicine
- Nancy Hall
- USDA/ARS/Children’s Nutrition Research Center, Baylor College of Medicine
- Liang Zhao
- Precision Medicine Research Center, Taihe Hospital
- Kwesi Marshall
- Tropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies
- Thaddaeus May
- USDA/ARS/Children’s Nutrition Research Center, Baylor College of Medicine
- Marvin E. Reid
- Tropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies
- Carolyn Taylor-Bryan
- Tropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies
- Xueqing Wang
- Department of Molecular and Human Genetics, Baylor College of Medicine
- John W. Belmont
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Yongtao Guan
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Mark J. Manary
- Departments of Paediatrics and Child Health and Community Health, University of Malawi
- Indi Trehan
- Departments of Paediatrics and Child Health and Community Health, University of Malawi
- Colin A. McKenzie
- Tropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies
- Neil A. Hanchard
- Department of Molecular and Human Genetics, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-13433-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The edematous form of severe acute childhood malnutrition (ESAM) presents with more severe multi-organ dysfunction than non-edematous SAM (NESAM). Here the authors assess genome-wide DNA methylation in buccal cells of SAM children and find that ESAM is characterized by hypomethylation at genes associated with disorders of nutrition and metabolism, including fatty liver and diabetes.
