Antihypoxic activity of zinc acetate complexes with N-allenyl- and N-isopropenylimidazoles on hypoxia models of various ethiology

Abstract

А comparative study of antihypoxic effect of complex compounds of zinc acetate with N-allenyland N-isopropenylimidazole, complexes immobilized on the sulfated arabinogalactan, and well-known antihypoxants, and/or antioxidants: ethomerzol, mexidol and nooglutyl has been conducted on nonlinear white mice-males in experiments. It is shown that in conditions of acute hypoxia of different Genesis, the complexes of zinc with N-alkenylmidazoles showed a pronounced antihypoxic effect in the dose range of 10–100 mg/kg, i/p, on 16–317% life span of animals increasing compared with the control groups of animals that surpasses the effect of known antihypoxants: etomerzol (25–100 mg/kg, i/p), mexidol (100 mg/kg, i/p) and nooglutyl (25–100 mg/kg, i/p). Complexes immobilized on the sulfated arabinogalactan were ineffective.

Keywords

• zinc
• complexes of zinc acetate with n-alkenylimidazoles
• antihypoxic activity
• sulfated arabinogalactan