Frontiers in Neuroscience (Sep 2022)
A long-term high-fat diet influences brain damage and is linked to the activation of HIF-1α/AMPK/mTOR/p70S6K signalling
- Fei Chen,
- Fei Chen,
- Fei Chen,
- Fei Chen,
- Fei Chen,
- Wen-min Yi,
- Wen-min Yi,
- Wen-min Yi,
- Wen-min Yi,
- Wen-min Yi,
- Sheng-yuan Wang,
- Sheng-yuan Wang,
- Sheng-yuan Wang,
- Sheng-yuan Wang,
- Sheng-yuan Wang,
- Ming-hao Yuan,
- Ming-hao Yuan,
- Ming-hao Yuan,
- Ming-hao Yuan,
- Ming-hao Yuan,
- Jie Wen,
- Jie Wen,
- Hong-Yan Li,
- Hong-Yan Li,
- Qian Zou,
- Qian Zou,
- Shu Liu,
- Shu Liu,
- Shu Liu,
- Shu Liu,
- Shu Liu,
- Zhi-you Cai,
- Zhi-you Cai,
- Zhi-you Cai,
- Zhi-you Cai,
- Zhi-you Cai
Affiliations
- Fei Chen
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Fei Chen
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Fei Chen
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Fei Chen
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Fei Chen
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Wen-min Yi
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Wen-min Yi
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Wen-min Yi
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Wen-min Yi
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Wen-min Yi
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Sheng-yuan Wang
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Sheng-yuan Wang
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Sheng-yuan Wang
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Sheng-yuan Wang
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Sheng-yuan Wang
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Ming-hao Yuan
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Ming-hao Yuan
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Ming-hao Yuan
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Ming-hao Yuan
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Ming-hao Yuan
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Jie Wen
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Jie Wen
- Department of Neurology, Guangdong Medical University, Zhanjiang, Guangdong, China
- Hong-Yan Li
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Hong-Yan Li
- Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
- Qian Zou
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Qian Zou
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Shu Liu
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Shu Liu
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Shu Liu
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Shu Liu
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Shu Liu
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- Zhi-you Cai
- Department of Neurology, Chongqing Medical University, Chongqing, China
- Zhi-you Cai
- Chongqing Institute Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
- Zhi-you Cai
- Chongqing School, University of Chinese Academy of Sciences, Chongqing, China
- Zhi-you Cai
- Department of Neurology, Chongqing General Hospital, Chongqing, China
- Zhi-you Cai
- Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China
- DOI
- https://doi.org/10.3389/fnins.2022.978431
- Journal volume & issue
-
Vol. 16
Abstract
High-fat diets (HFDs) are related to the incidence of obesity and diabetes, but the effect of high-fat diet-induced brain damage remains to be clarified. In our study, we found that 24 weeks of a HFD effectively induced obesity and a change in fur color in mice. In addition, the mice also exhibited deficits in learning and memory. We further found that autophagic flux was impaired in mice after HFD feeding. Hypoxia-inducible factor 1α (HIF-1α) expression was significantly increased in HFD-fed mice, and HFD feeding inhibited adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and induced mechanistic target of rapamycin (mTOR) phosphorylation and p70S6K expression. Treatment of HFD-induced BV2 cell model with palmitic acid (PA) was used to further verify a similar result. We concluded that improving tissue hypoxia or enhancing autophagy through the AMPK/mTOR/p70S6K pathway may be a relevant strategy for improving obesity- and ageing-related disorders.
Keywords
