Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1

Rajeshwer S. Sankhala; Ravi K. Lokareddy; Salma Begum; Ruth A. Pumroy; Richard E. Gillilan; Gino Cingolani

doi:10.1038/s41467-017-01057-7

Nature Communications (Oct 2017)

Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1

Rajeshwer S. Sankhala,
Ravi K. Lokareddy,
Salma Begum,
Ruth A. Pumroy,
Richard E. Gillilan,
Gino Cingolani

Affiliations

Rajeshwer S. Sankhala: Department of Biochemistry and Molecular Biology, Thomas Jefferson University
Ravi K. Lokareddy: Department of Biochemistry and Molecular Biology, Thomas Jefferson University
Salma Begum: Department of Biochemistry and Molecular Biology, Thomas Jefferson University
Ruth A. Pumroy: Department of Biochemistry and Molecular Biology, Thomas Jefferson University
Richard E. Gillilan: Macromolecular Diffraction Facility, Cornell High Energy Synchrotron Source (MacCHESS), Cornell University
Gino Cingolani: Department of Biochemistry and Molecular Biology, Thomas Jefferson University

DOI: https://doi.org/10.1038/s41467-017-01057-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α isoforms.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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