Nature Communications (Apr 2019)
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
- Alessandro Pastore,
- Federico Gaiti,
- Sydney X. Lu,
- Ryan M. Brand,
- Scott Kulm,
- Ronan Chaligne,
- Hongcang Gu,
- Kevin Y. Huang,
- Elena K. Stamenova,
- Wendy Béguelin,
- Yanwen Jiang,
- Rafael C. Schulman,
- Kyu-Tae Kim,
- Alicia Alonso,
- John N. Allan,
- Richard R. Furman,
- Andreas Gnirke,
- Catherine J. Wu,
- Ari M. Melnick,
- Alexander Meissner,
- Bradley E. Bernstein,
- Omar Abdel-Wahab,
- Dan A. Landau
Affiliations
- Alessandro Pastore
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Federico Gaiti
- New York Genome Center
- Sydney X. Lu
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Ryan M. Brand
- New York Genome Center
- Scott Kulm
- Weill Cornell Medicine
- Ronan Chaligne
- New York Genome Center
- Hongcang Gu
- Broad Institute of MIT and Harvard
- Kevin Y. Huang
- New York Genome Center
- Elena K. Stamenova
- Broad Institute of MIT and Harvard
- Wendy Béguelin
- Weill Cornell Medicine
- Yanwen Jiang
- Weill Cornell Medicine
- Rafael C. Schulman
- New York Genome Center
- Kyu-Tae Kim
- New York Genome Center
- Alicia Alonso
- Weill Cornell Medicine
- John N. Allan
- Weill Cornell Medicine
- Richard R. Furman
- Weill Cornell Medicine
- Andreas Gnirke
- Broad Institute of MIT and Harvard
- Catherine J. Wu
- Broad Institute of MIT and Harvard
- Ari M. Melnick
- Weill Cornell Medicine
- Alexander Meissner
- Broad Institute of MIT and Harvard
- Bradley E. Bernstein
- Broad Institute of MIT and Harvard
- Omar Abdel-Wahab
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Dan A. Landau
- New York Genome Center
- DOI
- https://doi.org/10.1038/s41467-019-09645-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
In chronic lymphocytic leukemia (CLL), evolution is driven by transcriptional and epigenetic heterogeneity. Here, the authors integrate epigenomic analyses to show how intra-tumoral epigenetic diversity results in divergent chromatin states in CLL cells, increasing cell-to-cell transcriptional heterogeneity.
