Similarity in viral and host promoters couples viral reactivation with host cell migration

Kathrin Bohn-Wippert; Erin N. Tevonian; Melina R. Megaridis; Roy D. Dar

doi:10.1038/ncomms15006

Nature Communications (May 2017)

Similarity in viral and host promoters couples viral reactivation with host cell migration

Kathrin Bohn-Wippert,
Erin N. Tevonian,
Melina R. Megaridis,
Roy D. Dar

Affiliations

Kathrin Bohn-Wippert: Department of Bioengineering, University of Illinois at Urbana-Champaign
Erin N. Tevonian: Department of Bioengineering, University of Illinois at Urbana-Champaign
Melina R. Megaridis: Department of Bioengineering, University of Illinois at Urbana-Champaign
Roy D. Dar: Department of Bioengineering, University of Illinois at Urbana-Champaign

DOI: https://doi.org/10.1038/ncomms15006
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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