The Expression of the Claudin Family of Proteins in Colorectal Cancer

Kristin E. Cox; Shanglei Liu; Robert M. Hoffman; Surinder K. Batra; Punita Dhawan; Michael Bouvet

doi:10.3390/biom14030272

Biomolecules (Feb 2024)

The Expression of the Claudin Family of Proteins in Colorectal Cancer

Kristin E. Cox,
Shanglei Liu,
Robert M. Hoffman,
Surinder K. Batra,
Punita Dhawan,
Michael Bouvet

Affiliations

Kristin E. Cox: Department of Surgery, University of California San Diego, La Jolla, CA 92037, USA
Shanglei Liu: Department of Surgery, University of California San Diego, La Jolla, CA 92037, USA
Robert M. Hoffman: Department of Surgery, University of California San Diego, La Jolla, CA 92037, USA
Surinder K. Batra: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Punita Dhawan: Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Michael Bouvet: Department of Surgery, University of California San Diego, La Jolla, CA 92037, USA

DOI: https://doi.org/10.3390/biom14030272
Journal volume & issue: Vol. 14, no. 3
p. 272

Abstract

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Claudins (CLDN1–CLDN24) are a family of tight junction proteins whose dysregulation has been implicated in tumorigeneses of many cancer types. In colorectal cancer (CRC), CLDN1, CLDN2, CLDN4, and CLDN18 have been shown to either be upregulated or aberrantly expressed. In the normal colon, CLDN1 and CLDN3–7 are expressed. Although a few claudins, such as CLDN6 and CLDN7, are expressed in CRC their levels are reduced compared to the normal colon. The present review outlines the expression profiles of claudin proteins in CRC and those that are potential biomarkers for prognostication.

Published in Biomolecules

ISSN: 2218-273X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: https://www.mdpi.com/journal/biomolecules

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