PLoS ONE (Jan 2014)

Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.

  • Xiangyi Kong,
  • Xiaofeng Xu,
  • Yuhua Yan,
  • Feifei Guo,
  • Jian Li,
  • Yali Hu,
  • Huaijun Zhou,
  • Qingying Xun

DOI
https://doi.org/10.1371/journal.pone.0090810
Journal volume & issue
Vol. 9, no. 3
p. e90810

Abstract

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MicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated in EC tissue and is highly expressed in estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression and functions as a tumour suppressor via the miR-30c-MTA-1 signalling pathway. Furthermore, miR-30c is decreased upon E2 treatment in both ER-positive Ishikawa and ER-negative HEC-1-B cells. Taken together, our results suggest that miR-30c is an important deregulated miRNA in EC and might serve as a potential biomarker and novel therapeutic target for EC.