The role of A268V exon-7 polymorphism of PPARA in development of axial spondyloarthritis

Abstract

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that mainly affects the axial skeleton. Peroxisome proliferator activated receptor alpha (PPARA) is an intracellular transcription factor, which play a role in inflammation and osteoblasting activity. This study is designed to investigate the relationship of NG_012204.2:p.Ala268Val polymorphism of PPARA with axSpA risk and its role in disease development.

Keywords

• axial spondyloarthritis
• disease risk
• inflammation
• peroxisome proliferator activated receptor alpha
• polymorphism
• aksiyal spondiloartrit
• hastalık riski
• enflamasyon
• peroksizom çoğaltıcılar tarafından aktive edilen reseptör alfa
• polimorfizm