Nature Communications (Jun 2019)
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
- Andrea Canal-Martín,
- Javier Sastre,
- María José Sánchez-Barrena,
- Angeles Canales,
- Sara Baldominos,
- Naiara Pascual,
- Loreto Martínez-González,
- Dolores Molero,
- Mª Encarnación Fernández-Valle,
- Elena Sáez,
- Patricia Blanco-Gabella,
- Elena Gómez-Rubio,
- Sonsoles Martín-Santamaría,
- Almudena Sáiz,
- Alicia Mansilla,
- F. Javier Cañada,
- Jesús Jiménez-Barbero,
- Ana Martínez,
- Ruth Pérez-Fernández
Affiliations
- Andrea Canal-Martín
- Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CIB-CSIC
- Javier Sastre
- Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CIB-CSIC
- María José Sánchez-Barrena
- Department of Crystallography and Structural Biology, Instituto de Química Física Rocasolano, IQFR-CSIC
- Angeles Canales
- Organic Chemistry Department, Universidad Complutense de Madrid
- Sara Baldominos
- Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CIB-CSIC
- Naiara Pascual
- Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CIB-CSIC
- Loreto Martínez-González
- Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CIB-CSIC
- Dolores Molero
- CAI de RMN, Universidad Complutense de Madrid
- Mª Encarnación Fernández-Valle
- CAI de RMN, Universidad Complutense de Madrid
- Elena Sáez
- CAI de RMN, Universidad Complutense de Madrid
- Patricia Blanco-Gabella
- Department of Crystallography and Structural Biology, Instituto de Química Física Rocasolano, IQFR-CSIC
- Elena Gómez-Rubio
- Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CIB-CSIC
- Sonsoles Martín-Santamaría
- Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CIB-CSIC
- Almudena Sáiz
- Instituto Ramón y Cajal de Investigación Sanitaria. Ctra. Colmenar Viejo, km. 9100
- Alicia Mansilla
- Instituto Ramón y Cajal de Investigación Sanitaria. Ctra. Colmenar Viejo, km. 9100
- F. Javier Cañada
- Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CIB-CSIC
- Jesús Jiménez-Barbero
- Molecular recognition and host-pathogen interactions, CIC bioGUNE
- Ana Martínez
- Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CIB-CSIC
- Ruth Pérez-Fernández
- Structural and Chemical Biology Department, Centro de Investigaciones Biológicas, CIB-CSIC
- DOI
- https://doi.org/10.1038/s41467-019-10627-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-1/Ric8a protein-protein interaction.
