Epilepsia Open (Jun 2023)

Real‐world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study

  • Fabienne Kühne,
  • Lena‐Luise Becker,
  • Thomas Bast,
  • Astrid Bertsche,
  • Ingo Borggraefe,
  • Christian Malte Boßelmann,
  • Jörg Fahrbach,
  • Christoph Hertzberg,
  • Nina A. Herz,
  • Martin Hirsch,
  • Martin Holtkamp,
  • Christine Janello,
  • Gerhard Josef Kluger,
  • Gerhard Kurlemann,
  • Holger Lerche,
  • Konstantin L. Makridis,
  • Felix vonPodewils,
  • Milka Pringsheim,
  • Susanne Schubert‐Bast,
  • Juliane Schulz,
  • Andreas Schulze‐Bonhage,
  • David Steinbart,
  • Bernhard J. Steinhoff,
  • Adam Strzelczyk,
  • Steffen Syrbe,
  • Heike De Vries,
  • Christiane Wagner,
  • Johanna Wagner,
  • Bernd Wilken,
  • Christine Prager,
  • Kerstin A. Klotz,
  • Angela M. Kaindl

DOI
https://doi.org/10.1002/epi4.12699
Journal volume & issue
Vol. 8, no. 2
pp. 360 – 370

Abstract

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Abstract Objective Cannabidiol (CBD) is approved for treatment of Dravet syndrome (DS), Lennox‐Gastaut syndrome (LGS), and tuberous sclerosis complex (TSC). Several studies suggest antiseizure effects also beyond these three epilepsy syndromes. Methods In a retrospective multicenter study, we analyzed the efficacy and tolerability of CBD in patients with epilepsy at 16 epilepsy centers. Results The study cohort comprised 311 patients with epilepsy with a median age of 11.3 (0‐72) years (235 children and adolescents, 76 adults). Therapy with CBD was off‐label in 91.3% of cases due to age, epilepsy subtype, lack of adjunct therapy with clobazam, and/or higher dose applied. CBD titration regimens were slower than recommended, with good tolerability of higher doses particularly in children. Of all patients, 36.9% experienced a reduction in seizure frequency of >50%, independent of their epilepsy subtype or clobazam co‐medication. The median observation period was 15.8 months. About one third of all patients discontinued therapy within the observation period due to adverse effects or lack of efficacy. Adverse effects were reported frequently (46.9%). Significance Our study highlights that CBD has an antiseizure effect comparable to other antiseizure medications with a positive safety profile independent of the epilepsy subtype. Comedication with clobazam was not associated with a better outcome. Higher doses to achieve seizure frequency reduction were safe, particularly in children. These findings call for further trials for an extended approval of CBD for other epilepsy subtypes and for children <2 years of age.

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