DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Julien M. D. Legrand; Ai-Leen Chan; Hue M. La; Fernando J. Rossello; Minna-Liisa Änkö; Frances V. Fuller-Pace; Robin M. Hobbs

doi:10.1038/s41467-019-09972-7

Nature Communications (May 2019)

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Julien M. D. Legrand,
Ai-Leen Chan,
Hue M. La,
Fernando J. Rossello,
Minna-Liisa Änkö,
Frances V. Fuller-Pace,
Robin M. Hobbs

Affiliations

Julien M. D. Legrand: Australian Regenerative Medicine Institute, Monash University
Ai-Leen Chan: Australian Regenerative Medicine Institute, Monash University
Hue M. La: Australian Regenerative Medicine Institute, Monash University
Fernando J. Rossello: Australian Regenerative Medicine Institute, Monash University
Minna-Liisa Änkö: Australian Regenerative Medicine Institute, Monash University
Frances V. Fuller-Pace: Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee
Robin M. Hobbs: Australian Regenerative Medicine Institute, Monash University

DOI: https://doi.org/10.1038/s41467-019-09972-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 21

Abstract

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Sustained sperm production is dependent on activity of undifferentiated spermatogonia. Here, the authors demonstrate an essential role for RNA helicase DDX5 in maintenance of spermatogonia in adults through control of gene transcription plus RNA processing and export.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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