Nature Communications (Jun 2022)
High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing
Abstract
Anti-cancer cytotoxic T cell responses largely vary among individuals. Here authors show, by stochastic modeling on high throughput T cell behavior and matched tumor spheroid fate data generated by a microfluidics system, that tumor killing is dependent on T cell cooperativity, which might contribute to the heterogeneity of T cell responses.