Coexistence of Light Chain and Transthyretin Cardiac Amyloidosis

Abhishek Gami, MD; John Woller, MD; Paul Scheel, MD; Syed Abbas Ali, MBBS; Carol Ann Huff, MD; Charles Steenbergen, Jr., MD, PhD; Marc Halushka, MD, PhD; Kavita Sharma, MD; Michael Polydefkis, MD; Joban Vaishnav, MD

JACC: Case Reports (Apr 2024)

Coexistence of Light Chain and Transthyretin Cardiac Amyloidosis

Abhishek Gami, MD,
John Woller, MD,
Paul Scheel, MD,
Syed Abbas Ali, MBBS,
Carol Ann Huff, MD,
Charles Steenbergen, Jr., MD, PhD,
Marc Halushka, MD, PhD,
Kavita Sharma, MD,
Michael Polydefkis, MD,
Joban Vaishnav, MD

Affiliations

Abhishek Gami, MD: Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
John Woller, MD: Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Paul Scheel, MD: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Syed Abbas Ali, MBBS: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Carol Ann Huff, MD: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Charles Steenbergen, Jr., MD, PhD: Department of Cardiovascular Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Marc Halushka, MD, PhD: Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA
Kavita Sharma, MD: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Michael Polydefkis, MD: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Joban Vaishnav, MD: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Address for correspondence: Dr Joban Vaishnav, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Carnegie 568E, Baltimore, Maryland 21287, USA.

Journal volume & issue: Vol. 29, no. 7
p. 102285

Abstract

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Although most patients with cardiac amyloidosis are diagnosed with either light chain (AL) or transthyretin (ATTR) disease, coexisting amyloid subtypes can occur. We present three cases of coexisting AL and ATTR cardiac amyloidosis and demonstrate the importance of clinical history and endomyocardial biopsy in diagnosis of this rare entity.

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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Abstract

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