Clinical role of endothelial dysfunction and hemostasis gene allelic variants in hepatitis C virus-associated cryoglobulinemia

Abstract

Aim of investigation. To estimate the effect of carriage of endothelial dysfunction and hemostasis gene allelic variants on development of cryoglobulinemic vasculitis (CryoVas) and its clinical symptoms in patients with chronic hepatitis C (CHC). Material and methods. Original study included overall 72 patients with CHC and cryoglobulinemia: 21 patients had CryoVas, 51 - CHC without vasculitis. Results. The T allele of NOS3 894 G/T gene was more frequent, T allele of ITGA2 807 C/T gene (OR =0.419) was less common and C allele of ITGB3 1565 T/C gene was more frequent (OR=2.33) in CryoVas patients. Multivariate assay revealed the number of mutant alleles («total score») of NOS3 894 G/T, ITGA2 807 C/T and ITGB3 1565 T/C genes as independent risk factor. The T allele of NOS3 894 G/T gene was found in patients with renal disease significantly less frequently (15% vs 45.5%; р=0.035) as well as in patients with systemic hypertension (30% and 72.7%; р=0.086). Conclusions. Carriage of GT genotype of NOS3 894 G/T gene and CC genotype of ITGB3 1565 T/C gene is associated with high risk of CryoVas development. The TT genotype of ITGA2 807 C/T gene possess «protective» properties. The «total score» is independent predictor of CryoVas development.

Keywords

• хронический гепатит с
• криоглобулинемический васкулит
• полиморфизм генов
• тромбофилия
• гемостаз
• тромбоцитарные рецепторы
• эндотелиальная дисфункция